Results for Activators & Inhibitors ( 79666 )
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VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP/TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.
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GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani at an IC50 of 0.16 μM, sandwiched between the β4 and β5 subunits. GSK3494245 exhibits good biosafety properties. GSK3494245 is a suitable inhibitor of the chymotrypsin-like activity of the human proteasome (IC50: 26S=13 μM; enriched THP-1 extract IC50=40 μM).
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Mt KARI-IN-5 (compound 6c) was a potent inhibitor of Mycobacterium tuberculosis ketohydrin reductase I (MtbKARI) (Ki: 4.72 μM). Mt KARI-IN-5 exhibited inhibition of MtbH37Rv activity with a MIC value of 1.56 μM, low cytotoxicity and an IC50 value for HEK The IC50 value for HEK was greater than 64 μg/mL.