Results for Activators & Inhibitors ( 79666 )
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This compound is a dual 5-HT1A/5-HT7 receptor antagonist (5-HT1A Ki = 8 nM, Kb = 0.04 nM; 5-HT7 Ki = 451 nM, Kb = 460 nM) with additional inhibitory activity against PDE4B/PDE7A (PDE4B IC50 = 80.4 μM; PDE7A IC50 = 151.3 μM). Its antidepressant-like effect surpasses that of the reference agent, escitalopram.
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Antitubercular agent-29 (compound 6xa) is a potent drug resistant (DR) Mycobacterium tuberculosis (Mtb) inhibitor. Antitubercular agent-29 exhibits MIC of 0.03 μg/mL against drug-susceptible (DS)-Mtb strains, MIC of 0.03-0.06 μg/mL against DR-Mtb strains. Antitubercular has favourable selectivity (SI>40) against Vero cells.
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HDAC-IN-47 is an orally active histone deacetylase (HDAC) inhibitor with IC50 values of 19.75 nM, 57.8 nM, 40.27 nM, 5.63 nM and 302.73 nM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. HDAC-IN-47 can block the cell cycle in G2/M phase, inhibit autophagy, induce apoptosis using the Bax/Bcl-2 and caspase-3 pathways, and has anti-cancer activity in vivo.