Activators & Inhibitors

Mitragynine pseudoindoxyl is a potent agonist of MOR with reduced hypermobility, inhibition of GI translocation and enhanced activity.

ANKRD22-IN-1 is a potent inhibitor of ANKRD22, which promotes the expansion of gastrointestinal mucosal epithelial stem cells and thus indirectly activates the Wnt classical pathway, which is beneficial for the recovery of damaged gastrointestinal mucosal tissue in vivo.

Renin inhibitor-1 (compound 26) is a potent, orally active renin inhibitor capable of acting on rh-renin (IC50: 0.9 nM) and hPRA (IC50: 1.8 nM). renal disease.

NDT-30805 is a triazolopyridine derivative that inhibits the release of IL-1β from PBMC (IC50: 0.013 μM).NDT-30805 is also a selective inhibitor of the NLRP3 inflammasome.NDT-30805 can be used to study inflammation and immunity.

HF50731 is a potent antagonist of CXCR4. HF50731 has a strong binding affinity for CXCR4 (IC50: 19.8 nM). HF50731 utilizes the CXCR4 co-receptor and effectively inhibits calcium mobilization (IC50: 119.2 nM), cell migration (IC50: 621.4 nM) and HIV-1 infection (IC50: 1.5 nM). IC50: 1.5 nM).

RBP4 ligand-1 is a non-retinoid ligand for retinol-binding protein 4 (RBP4). hRBP4SPAIC50 and RBP4-TTR FRET IC50 values were 0.23±0.11 and 0.13±0.12 μM for the radioligand binding assay and FRET assay, respectively. 0.12 μM.

COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.

LP-922761 hydrate is a selective, potent, orally active AAK1 inhibitor with IC50 values of 4.8 nM and 7.6 nM in enzyme and cellular assays, respectively. LP-922761 hydrate inhibits BMP-2 inducible protein kinase (BIKE) (IC50: 24 nM). 922761 hydrate has no significant effect on cellular GAK, opioids, adrenergic α2 or GABAa receptors.

HBV-IN-12 is a potent inhibitor of hepatitis B surface antigen (HBsAg).