PROTAC FAK degrader 1
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
PROTAC K-Ras Degrader-1
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
PROTAC SGK3 degrader-1
PROTAC SGK3 degrader-1, is a potent SKG3 degrader based on PROTAC.
PROTAC BET Degrader-1
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
PROTAC BET degrader-3
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
SMARCA-BD ligand 1 for Protac dihydrochloride
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
PROTAC BRD9-binding moiety 1 hydrochloride
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
PROTAC ERRα ligand 1
PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively).
Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].