Chemicals

Farnesoic acid ((2E 6E)-3 7 11-trimethyldodeca-2 6 10-trienoic acid) is the substrate of farnesoic acid O-methyltransferase which produces the crustacean reproductive hormone methyl farnesoate (MF). MF is responsible for enhancing reproductive maturation maintaining juvenile morphology and influencing male sex determination. Farnesoic acid also inhibits filiment formation in C. albicans. Powered by Bioz See more details on BiozFeatured in Publications1) Li Y. G. C. Unnithan et al. (2003). "Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin." J Exp Biol 206(Pt 11): 1825-32.2) Zhao N. J. Guan et al. (2007). "Molecular cloning and biochemical characterization of indole-3-acetic acid methyltransferase from poplar." Phytochemistry 68(11): 1537.3) Chung S.-C. T.-I. Kim et al. (2010). "Candida albicans PHO81 is required for the inhibition of hyphal development by farnesoic acid." FEBS letter

Methyl farnesoate (MF) is a crustacean reproductive hormone that is structurally similar to insect juvenile hormone. It is responsible for enhancing reproductive maturation maintaining juvenile morphology and influencing male sex determination. Exposure of female Daphnids to increasing levels of MF increases the percentage of males in a brood in a dose-dependant manner. MF is endogenously produced in the mandibular organ and environmental factors such as salinity and temperature can influence hemolyph levels. Powered by Bioz See more details on BiozFeatured in Publications1) Olmstead A. W. and G. A. LeBlanc (2007). "The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean." Int J Biol Sci 3(2): 77-84.2) Eads B. D. J. Andrews et al. (2007). "Ecological genomics in Daphnia: stress responses and environmental sex determination." Heredity 100(2): 184.3) Nagaraju G. P. C. and D. W. Borst (2008). "Methyl farnesoate couples environmental changes to testicular d

Nanocs provides a variety of chemically functionalized and bioconjugated dextran products with molecular weight ranged from 3,000 Da to 2,000 KDa. These functional dextrans were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo. Dextrans are naturally synthesized polysaccharides with good water solubility, low toxicity and varied molecular weights. Dextrans modified with dyes and other biomolecules have been successfully used as long-term tracers for live cells.

This novel and selective probe for hydrogen sulfide (H2S) 7-azido-4-methylcoumarin (AzMC) is useful for monitoring cystathionine B-synthase (CBS) catalyzed reactions which play a critical role in human sulfur metabolism. Deactivated CBS is characterized by high plasma levels of homocysteine and H2S resulting in clinical manifestations of numerous disease states. AzMC used as a fluorgenic probe and concurrent CBS activity can be used to select compounds for activation or inhibition of this enzyme and is suitable for high-throughput screening and the development of potential therapeutics. In addition AzMC has been used as a photoaffinitry probe for the substrate binding site of human phenol sulfotransferase (SULT1A-1 or P-PST-1).Featured in References1. M.K. Thorson T. Majtan J.P. Kraus A.M. Barrios "Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe." Angewandte Chemie (Int. ed. Eng.) 2013 52 4641-4144. DOI: 10.1002/anie.20130084

C6NIB is a fluorescence turn-on sensor that is suited for trace vapor detection of hydrogen peroxide (H2O2). The sensor mechanism is based on H2O2-mediated oxidation of the boronate fluorophore C6NIB which is nonfluorescent in the ICT band but is strongly fluorescent upon conversion to the phenol (C6NIO). The fluorescence turn-on reaction is extremely sensitive towards H2O2 with no sensor response to other common reagents. The negligible fluorescence background of C6NIB combined with the high fluorescent emission of C6NIO makes it an ideal candidate for efficient sensing. Dispersing C6NIB with TBAH into a silica gel matrix produces a highly efficient sensor for vapor detection of H2O2 in terms of detection limit (2.9 ppb) and response time (1 sec. under 1 ppm H2O2).References:M. Xu J-M. Han et al.“A selective fluorescence turn-on sensor for trace vapor detection of hydrogen peroxide” Chem. Commun. 2013 49 11779-11781.