Bioconjugation Kits

MagicLink™ Site Specific Biotinylation Kits provide optimized reagents for biotinylating antibodies. Biotin is a small, naturally occurring vitamin that binds with high affinity to avidin and avidin-like proteins. Biotinylated antibodies typically retain biological activity because the biotin group is relatively small. Current bintinylation methods, such as amine-NHS ester and converting amine to thiol and then use maleimide chemistry, will produce random biotin on the antibody. In some cases, labeling in some Fab areas could block antigens binding. With site specific biotinylation chemistry, biotin linkers are inserted to thiol-bridge locations and do not affect antibody-antigen binding (Fig.1). It will help increase the sensitivity of bio assay such as ELISA, Western Blot, etc. This conjugation reaction is simple, site-specific, and efficient. These kits include biotin linker, reaction buffer, protein concentrator, DMSO, and TCEP. The user can follow easy protocol and get the conjuga

MagicLink™ Site Specific Biotinylation Kits provide optimized reagents for biotinylating antibodies. Biotin is a small, naturally occurring vitamin that binds with high affinity to avidin and avidin-like proteins. Biotinylated antibodies typically retain biological activity because the biotin group is relatively small. Current bintinylation methods, such as amine-NHS ester and converting amine to thiol and then use maleimide chemistry, will produce random biotin on the antibody. In some cases, labeling in some Fab areas could block antigens binding. With site specific biotinylation chemistry, biotin linkers are inserted to thiol-bridge locations and do not affect antibody-antigen binding (Fig.1). It will help increase the sensitivity of bio assay such as ELISA, Western Blot, etc. This conjugation reaction is simple, site-specific, and efficient. These kits include biotin linker, reaction buffer, protein concentrator, DMSO, and TCEP. The user can follow easy protocol and get the conjuga

BroadPharm's SN-38 Antibody Conjugation kit attaches the drug, SN-38 to antibody. The kit is designed to utilize the linker's maleimide group to react and attach to thiol groups on the antibody. The linker- SN-38 is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11 ), and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.

BroadPharm's SN-38 Antibody Conjugation kit attaches the drug, SN-38 to antibody. The kit is designed to utilize the linker's maleimide group to react and attach to thiol groups on the antibody. The linker- SN-38 is made by SN38 conjugated to the lysosomally cleavable dipeptide, valine-citrulline (vc) linker. SN-38 is the active metabolite of the topoisomerase-I (topo-I) inhibitor Irinotecan (CPT-11 ), and it stabilizes the complex between topo-I and DNA which collide with moving DNA replication forks, eventually leading to double stranded DNA damage.

Link-Dtech 545-Tb (Green) kit is coupled with Bright-Dtech 545 for obtaining a labeling of antibodies, peptides, oligonucleotides and proteins. The kit is perfect for the need of small-volume fast labeling, for TRF assay development (FRET, FLISA, WB, LF, DB). You can find in the kit all the materials necessary for the labeling process (except purification products)

Link-Dtech 575-Dy (Yellow) kit is coupled with Bright-Dtech 575 for obtaining a labeling of antibodies, peptides, oligonucleotides and proteins. The kit is perfect for the need of small-volume fast labeling, for TRF assay development (FRET, FLISA, WB, LF, DB). You can find in the kit all the materials necessary for the labeling process (except purification products)

Link-Dtech 600-Sm (Orange) kit is coupled with Bright-Dtech 600 for obtaining a labeling of antibodies, peptides, oligonucleotides and proteins. The kit is perfect for the need of small-volume fast labeling, for TRF assay development (FRET, FLISA, WB, LF, DB). You can find in the kit all the materials necessary for the labeling process (except purification products)

Link-Dtech 614-Eu (Red) kit is coupled with Bright-Dtech 614 for obtaining a labeling of antibodies, peptides, oligonucleotides and proteins. The kit is perfect for the need of small-volume fast labeling, for TRF assay development (FRET, FLISA, WB, LF, DB). You can find in the kit all the materials necessary for the labeling process (except purification products)

Link-Dtech 880-Nd (Infrared) kit is coupled with Bright-Dtech 880 for obtaining a labeling of antibodies, peptides, oligonucleotides and proteins. The kit is perfect for the need of small-volume fast labeling, for TRF assay development (FRET, FLISA, WB, LF, DB). You can find in the kit all the materials necessary for the labeling process (except purification products)