Page 42 - Scientific Library
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
Antibody arrays: a matter of species
Research is never easy. That's why we either like doing it or supporting it.
That said, it's easier for some researchers than others. If you are working on human, mouse or even rat models, you have quite
Gateway® cloning technology: Is it as easy as they say?
Molecular biology experts have been telling us for a while that the Gateway® cloning vectors are easy-to-use, saving them significant time and effort.
Basically, the technology allows you to start with
Measure antioxidative capacities of your samples
Free radicals and Reactive Oxygen Species (ROS) are highly reactive molecules generated by normal cellular processes, environmental stress, and UV irradiation. ROS react with numerous cellular components
HSCI's researchers switch skin cells into pain-sensing neurons
In a recent publication, Dr Clifford J. Woolf's
6 Tips for a successful ELISA
ELISA are immunoassays widely used in biomarker detection and validation. They have been used in research and clinical settings for more than 40 years, and they allow to quantify, in a simple way, thousands
The TRPV1 Pain Receptor activates T cells
The Transient Receptor Potential (TRP) ion channel family participates in numerous functions of the Nervous System. A recent publication tends to indicate that TRP might also be of interest for therapeutical
Where can I find the best PARPs?
Poly (ADP-ribose) polymerase (PARP) is a family of proteins which catalyze the NAD-dependent addition of Poly ADP-ribose (PAR) chains to nuclear proteins. PARPs play key signaling roles in apoptosis,
Glycosylation studies in the inflammasome
In a previous post on tumour microenvironment (TME) and glycosylation, we indicated that new tools for studies on glycosylation of proteins were being developed. We are happy to announce that they are
Immunotherapy Screening - GITR:GITRL pathway
In previous blogs, I invited you to read about the relevance of the B7-1 : CD28, B7-1 : CTLA4, the BLTA:HVEM, CD47:SIRPα , and the PD-1/PD-L1/PD-L2 pathway for immunotherapy screenings and discussed