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Paez-Gonzalez et al. (Duke University) have discovered a new population of choline acetyltransferase (ChAT)+ neurons present in the rodent subventricular zone (SVZ). (1) This niche is known

Hyaluronic acid (also called HA or Hyaluronan) is a glycosaminoglycan with unique characteristics. HA possesses elevated viscosity, enabling tissues (eye, skin, joint and synovial fluid...) to resist

Professor Alan Clarke, (Director of the European Cancer Stem Cell Research Institute) has recently given an overview of how Cancer Stem cell tumors differ from the conventional "homogenous bulk cancer

Deak AT et al. decipher the mechanisms by which mitochondria contribute to Ca2+ intracellular signaling. In their recent paper (1), they show that mitochondrial "Ca2+ buffering" close to the Endoplasmic

The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines,

Proteome is referenced as the result of expression of the whole genome. With the recent developments of genomics, one could consider that this analysis is enough to decipher any biological mechanism...

Celastrol is a biologically active substance initially described in the traditional Chinese medicine. Celastrol (or (9ß,13α,14ß,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic

Collagen is a structural protein expressed in mammalian tissues (ex. skin, muscles, tendons, ligaments, cartilages, blood vessels...).  Together with Elastin and Keratin, Collagen fibres give connective

Ubiquitin (Ub) is an 8 kDa  highly conserved polypeptide, commonly expressed in eukaryotic cells. Ub is added to lysine residues of the target proteins. This post-translational modification (known

The synergistic combination of Poly(ADP-ribose) polymerases (PARP) and Topoisomerase I (Top1) inhibitors most beneficial on endonuclease-deficient cancer cells in cancer therapies ?

This is one of the

In my previous post, we focused on 6 cytokine growth factors for cell culture. This time, we will try to find the best factor for each main cell type.

• Established Cell Lines:  this established cell culture

Histone-lysine N-methyltransferase EZH2  is a methyltransferase involved in transcriptional gene regulation. Together with with EED, RbAP48, SUZ12 and AEBP2, EZH2 forms a 5-member complex that adds