Page 49 - Genomics & Genetics
New hope for Ras inhibitors
Ras belongs to the family of small G-proteins and plays an important role in several signal transduction pathways involved in normal cell growth and differentiation. Over 30 years ago three isoforms of
Why multiplex histone binding arrays?
In the summer of 2013, my colleague Frederic Dubor, who is in charge of our services lab, mentioned to me that he had just been asked by 3 clients within a very short time-frame, whether our laboratory
5 new research tools to perform chromatin and epigenetic analysis
Nucleosomes are core particles involved in DNA packaging in eukaryotic cells. They affect gene expression levels by regulating access of DNA to transcription factors and DNA binding proteins. Nucleosome
Pooling samples for proteomics - biomarker profiling case studies
To pool or not to pool biological samples? This question might pop up in the mind of anyone designing biomarker discovery approaches!
Much debate has been raised on biomarker discovery from clinical
Specific cytokines & growth factors in... apoptosis!
Apoptosis is the process of programmed cell death. Upon induction of apoptotic processes, cell undergo characteristic morphological changes (blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation,
Immunotherapy Screening - A focus on PD-1/PD-L1/PD-L2 Pathway in drug discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Immunotherapy Screening - B7-1 / CD28 and B7-1 / CTLA4 Pathways in Drug Discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
How to measure Calcium in cell based assays?
In Pharma screening departments there is a strong need for Ca2+ measurement methods.
Why is this?
Specific cytokines & growth factors in... hematology!
Hematology is the study of blood, blood-forming organs and blood diseases. The formation of blood cells is referred to as hematopoiesis. All cellular components of the blood are derived from hematopoietic
Focus on the Hypoxia Pathway...
Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. Therefore, reliable markers for hypoxia represent both valuable diagnostic markers
Specific cytokines & growth factors in... neurobiology!
Neurobiology is the study of cells of the nervous system and their organization into functional circuits that process information and mediate behavior.
Neurotrophic factors
Human Primary Sebocyte assay for compound testing on lipid metabolism
Sebocytes belong to the epidermal ecosystem together with hair follicules or in sebaceous glands. Sebocytes play a key role in skin health by producing sebum. These cells are now at the center of researchers'