Page 52 - ADME/Tox

In a recent paper published in PNAS, Wang et al. show that the inhibition of the deubiquitinase USP9x by the small molecule WP-1130 is able to induce degradation of the transcription factor E-twenty-six

Cytokines and growth factors are signaling molecules that control the activities of cells through intercellular communication. Numerous families of diverse molecules are categorized as cytokines and/or

It's official, CRISPR has officially reached "Breakout" status as a Google search term (see image from Google Trends). The Clustered,

Protein phosphorylation analysis is  more and more used for cell signaling studies. This post-translational modification regulates the function of numerous proteins in both physiological and disease-related

Bioactive small molecules facilitate numerous types of Life Science research approaches (enzyme substrates, activators and inhibitors, cell signaling modulator, cell culture...). Accessing reasonably priced,

In a previous post I discussed 3 new unique research tools

AKT (Protein Kinase B or PKB), is a serine/threonine-specific protein kinase with known key involvement in glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

Methods commonly used for the characterization of iPS or ES cells are based on specific antibody staining

The availability of human peripheral blood mononuclear cells (PBMC) from healthy individuals and from patients with various diseases allows for many studies on normal and abnormal functions of human immune

The Notch signaling pathway plays a vital role in the regulation of asymmetric cell division, cell fate specification and proliferation. Mammals possess 4 different Notch receptors, referred to as Notch1,

An interesting poster has recently been published by XenoTech: "Selection of Human Liver S9 and Cytosol Fractions for Evaluating Clearance by Aldehyde Oxidase (AO): The Impact of Low Versus High AO Activity