Page 44 - ADME/Tox

Poly (ADP-ribose) polymerase (PARP) is a family of proteins which catalyze the NAD-dependent addition of Poly ADP-ribose (PAR) chains to nuclear proteins. PARPs play key signaling roles in apoptosis,

The Transient Receptor Potential (TRP) ion channel family participates in numerous functions of the Nervous System. A recent publication tends to indicate that TRP might also be of interest for therapeutical

ELISA are immunoassays widely used in biomarker detection and validation. They have been used in research and clinical settings for more than 40 years, and they allow to quantify, in a simple way, thousands

In a recent publication, Dr Clifford

tebu-bio signed recently a distribution agreement with HemaCare Corp. Built on a 36-year history in apheresis collection, HemaCare is a leader in cell and tissue collection and processing, providing high-quality

Free radicals and Reactive Oxygen Species (ROS) are highly reactive molecules generated by normal cellular processes, environmental stress, and UV irradiation. ROS react with numerous cellular components

One of the questions we usually get in the Biomarkers team, once researchers or clinicians have done profiling arrays (e.g. for secretome and kinome), is how to interpret,

Molecular biology experts have been telling us for a while that the Gateway® cloning vectors are easy-to-use, saving them significant time and effort.

Basically, the technology allows you to start

Research is never easy. That's why we either like doing it or supporting it.

That said, it's easier for some researchers than others. If you are working on human, mouse or even rat models, you have

DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation

A lot of efforts are made to identify potent and selective inhibitors for the demethylation reactions catalyzed by members of the JMJD2 and JARID1 protein families (1, 2). Both

We all react to external factors, even the most cold-blooded person. We might hide our emotions, but there they are.

The same happens in cancer. Cells (both the tumour cells and the normal ones)