Page 41 - ADME/Tox
Diluting samples for proteomics – biomarker profiling case studies (I)
To dilute or not to dilute biological samples? And if yes, how much? That's the question!
Following our post on whether samples should be pooled or not when performing studies for
Genome Editing in Stem Cells: outsource or do-it-yourself?
Many researchers are facing a dilemma: they want to set up a CRISPR genome editing project but they can't decide which cell line to use for genome editing. Even some of the most cost-effective genome editing
PGE2 role in carcinoma chemoresistance via CSC repopulation
The involvement of Prostaglandin E2 (PGE2) in cancer development has already been described (see the post "Tumour
Antibiotics and microbial metabolites - revisited
What are metabolites?
Microorganisms live in a world of chemical signals. They use small molecular weight compounds, known as metabolites, to regulate their own growth and development,
7 popular phospho-specific antibodies
Whatever the research domain (oncology, cardiovascular diseases, Diabetis/obesity, inflammation, autoimmune disorders...), phosphorylation study is essential when looking for activation of cell signaling
5 reasons to prefer custom rec. protein production to commercial
Many recombinant proteins (rec. proteins) are now commercially available. And many of them, mainly secreted soluble proteins, are biologically active, so there shouldn't be any need to look for alternatives
Alternatives to the "mega-brands" of molecular biology
If you don't buy luxury brand clothes, why are you still buying luxury brand molecular biology kits?
Let me guess... you might use those blue and red boxed Qiagen® kits for DNA and RNA purification,
Adenovirus: weapons of mass transduction for gene delivery
Adenovirus (AV) are non-enveloped and non-integrative icosaedral viruses. Recombinant AV (genetically modified with respect to the wild-type in order to lose their capacity of replication) are widely used
Exosomes as a trigger for signaling
Extracellular vesicles in general, or exosomes in particular, are becoming a hot topic for research, especially in cancer. They seem to have different roles in tumour progression or can
Capping, bundling, sequestering... the role of Actin Binding Proteins
Actin binding proteins (ABPs) have a wide variety of functions in regulating the cellular function of actin. They control G-actin polymerization but also drive actin filaments severing and cross-linking
Tumour microenvironment - ameloblastomas
Following our post on tumour microenvironment and glioblastoma, we will focus today on ameloblastomas.
Ameloblastomas are benign tumours that occur in the jawbone, and invade bone.