Page 43 - ADME/Tox

Cell culture under oxygen controlled conditions: an improvement towards more predictive results

Oxygen concentration in tissues is a key factor for cell and organ survival. In normal conditions,

Hyaluronic acid (HA), or hyaluronan, is an ubiquitous, very high molecular mass polysaccharide that has applications

In my previous blogs, I invited you to read about the relevance of the B7-1

During the last International Federation of Societies of Cosmetic Chemists (IFSCC) congress (Paris, Oct. 2014), Hajem N. et al (ALES Groupe) have shown that by enhancing MDR activity of fibroblasts

A previous post explained how samples obtained from patients treated with mAbs can show interference with WB & ELISA methods. More rarely, we can also find other interference effects

As discussed in previous posts, use of new tools allows the finding of new disease-related biomarkers. Today, we want to put our spotlight on esophageal cancer.

Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.

In this paper (Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death), Voccoli et al. used Human oligodendrocyte MO3.13 cells to study Globoid cell leukodystrophy.

Globoid cell leukodystrophy (GLD) is a metabolic disease caused by mutations in the galactocerebrosidase (GALC) gene. GALC is a lysosomal enzyme whose function is to degrade galacto-lipids, including galactosyl-ceramide and galactosyl-sphingosine (psychosine, PSY). GALC loss of function causes progressive intracellular accumulation of PSY. It is widely held that PSY is the main trigger for the degeneration of myelinating cells and progressive white-matter loss. However, still little is known about the molecular mechanisms by which PSY imparts toxicity. In this paper, the role of calcium dynamics during PSY-induced cell death is addressed. Using the human oligodendrocyte cell line MO3.13, the authors report that cell death by PSY is accompanied by robust

ISG15 ubiquitin-like modifier (ISG15) functions intracellularly as a Ubiquitin homologue and a cytokine. ISG15 induces production of IFN-gamma and augments NK/lymphokine-activated killer cell proliferation

As part of the innate immune response, Toll-like receptor 9 recognizes unmethylated CpG nucleotide sequences, which are very common in viruses and prokaryotes and more rare in vetebrates. Scientists routinely

In previous blogs, I invited you to read about the relevance of the B7-1

In a previous post on tumour microenvironment (TME) and glycosylation, we indicated that new tools for studies on glycosylation of proteins were being developed. We are happy to announce