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Leading on from my previous posts (see below) exploring microRNA detection, overexpression and inhibition, this time, let's spend a moment on target detection.

miTarget databases

There are many online

Antibody pairs have been used for years to detect biomarkers in biological samples. They are a convenient and price-wise alternative to ready-to-use ELISAs, especially when they are used on a routine basis

The cellular and physiological effects resulting from hypoxia-dependent networks have been clearly shown to impact a number of human pathological states, including ischemic disease, diabetes, pulmonary

The Histone Demethylase FBXL10 (also known as NDY1, KDM2B, or JHDM1B) has been reported to demethylate histone H3K4me3.  By removing active Methyl Epigenetic marks on the chromatin, this "Epigenetic

Several lines of evidence show that synthetic lethal interactions targeting DNA repair pathways may have clinical applications in cancer therapy. In a recent paper, Albarakati et al. demonstrate that

Well, in the previous posts leading up to this final one in the series, we looked at microRNA detection, overexpression, inhibition, and target detection. I'd like to finish by going over miRNA profiling.

Following a post on tools for discovery of secretome biomarkers in biological samples, a recent publication by Torres et al. depicts how some of these tools (i.e. antibody arrays) can be used to find new

DNA topoisomerase I and DNA topoisomerase II (Topo I and Topo II) are nuclear enzymes which regulate the topological state of the DNA helix by transiently breaking and rejoining DNA strands. They also

In a previous post on Cellular Matrices for Translational Research, I introduced HyStem hydrogels.  In order to engineer a custom culture system with HyStem, simple pilot studies or optimization

In the past, molecular motor proteins like kinesins have been investigated with macromolecular approaches. Recent research on kinesins has been focused on resolving how kinesin is regulated by intramolecular