Antibiotics & Metabolites

Activity: Purine antimetabolite and immunomodulator . Function/Pharmacology: Purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.1 It inhibits DNA synthesis by inhibiting the production of purine containing nucleotides. The immunomodulatory activity of 6-Mercaptopurine is mainly the result of the 6-MP metabolite 6-thioguanine triphosphate (6-TGTP) binding to small GTPase Rac1.2 Chemical Name: 3,7-Dihydropurine-6-thione monohydrate

Antimicrobial spectrum: Gram-positive and Gram-negative bacteria, Pseudomonas

beta-lactam antibiotic

against mycobacteria

CC-17369, also known as pomalidomide m16 or Pomalidomide metabolite M16, is a bio-active chemical.

Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM.

Antibiotic YC 17 is a biochemical agent.

Antibiotic Z-1159-1 is an agent of biochemical.

Antibiotic K 4 is an inhibitor of angiotensin I converting enzyme produced by Actinomadura spiculosospora.