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    Results for Chemicals ( 1318 )

      • Squalene purified

        Ref: S-0300
        Sizes: 10 mg

        Squalene is a naturally occurring triterpenoid synthesized from two molecules of farnesyl diphosphate (FPP) by squalene synthase. Echelon's squalene has been further purified to remove oxidized byproducts.Featured in publications1) Howlader DR Das S Lu T Hu G Varisco DJ Dietz ZK Walton SP Ratnakaram SSK Gardner FM Ernst RK Picking WD and Picking WL (2021) Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas Aeruginosa. Front. Pharmacol. 12:706157. doi: 10.3389/fphar.2021.706157

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      • 2 3-Oxidosqualene (racemic)

        Ref: S-0301
        Sizes: 1 mg, 10 mg

        2 3-Oxidosqualene is an important intermediate in the biosynthesis of membrane sterols being converted to lanosterol by 2 3-oxidosqualene cyclase. The (S)-enantiomer is formed by oxidation of squalene by monooxygenase. 2 3-(R)-oxidosqualene is an inhibitor of lanosterol synthase Powered by Bioz See more details on Bioz

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      • 2 3 22 23-Dioxidosqualene

        Ref: S-0302
        Sizes: 1 mg

        2 3 22 23-Dioxidosqualene (mixture of diastereomers) is a substrate for oxidosqualene cyclase forming 24 25-oxidolanosterol. Powered by Bioz See more details on Bioz

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      • Tea polyphenol

        Ref: S00015
        Sizes: 1 mL

        Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number

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      • PROTAC Bcl2 degrader-1

        Ref: T10485
        Sizes: 1 mg, 5 mg, 10 mg

        PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).

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      • CDK ligand for PROTAC hydrochloride

        Ref: T10734L
        Sizes: 5 mg, 25 mg, 100 mg, 50 mg, 10 mg, 1 mL

        CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

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      • FKBP12 PROTAC dTAG-13

        Ref: T11291
        Sizes: 1 mg

        FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.

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      • FKBP12 PROTAC dTAG-7

        Ref: T11292
        Sizes: 5 mg, 2 mg

        FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest.

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      • PROTAC Mcl1 degrader-1

        Ref: T11975
        Sizes: 1 mg, 5 mg, 10 mg

        PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.

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