Nucleic Acids

DNA Please note this product may be subject to fees, we invite you to contact your local office.

DNA Please note this product may be subject to fees, we invite you to contact your local office.

DNA Please note this product may be subject to fees, we invite you to contact your local office.

DNA Please note this product may be subject to fees, we invite you to contact your local office.

DNA Please note this product may be subject to fees, we invite you to contact your local office.

DNA Please note this product may be subject to fees, we invite you to contact your local office.

CleanCap® Reagent M6 [CleanCap m6AG (3’ OMe)], is designed for the co-transcriptional capping of mRNA to produce an mRNA with base modified Cap 1. Cap 1 mRNAs have superior in vivo activity compared to Cap 0 mRNAs produced by legacy capping methods. The addition of a methyl group on position 6 of the first adenosine (m6A) may further increase protein expression relative to CleanCap AG or CleanCap AG (3’OMe). It has been hypothesized that the m6A modification adjacent to the 7-methylguanosine cap can positively influence mRNA stability by preventing enzyme-mediated decapping (Mauer et al. 2017)​ CleanCap M6 uses the same 5’ AG initiation sequence as CleanCap AG and CleanCap AG (3’OMe). ​ CleanCap has been shown to provide > 95% capping efficiency and typical crude yields of 4 mg to 5 mg per mL of transcription.​ CleanCap M6 can be used in conjunction with wildtype bases or TriLink’s catalog of modified NTPs, such as N1-Methylpseudouridine-5’-Triphosphate (N-1081), Pseudouridine-5’-Tr

Expresses no protein, can be used as a negative control.

Pre-Mixed Methylation Standards containing 0%, 10%, 25%, 50%, 75%, 90%, and 100% methylation; for Cancer