Click Chemistry

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Tucatinib acts as an HER2 inhibitor, and in BT474 breast carcinoma cells, it effectively suppresses HER2 phosphorylation. Tucatinib inhibits AKT phosphorylation and induces apoptosis in BT474 cells, rendering it a viable cytotoxic agent for formulating antibody-drug conjugates (ADCs).

SPDB-DM4 represents an linker-payload in which the maytansine-derived payload DM4, known for its tubulin-inhibiting properties, is linked via an SPDB linker, resulting in a highly effective treatment with strong anti-tumor capabilities. It is suitable to be conjugated into antibody drug conjugates (ADCs).

t-Butoxycarbonyl-PEG4-Ala-Ala-Asn is a cleavable PEG ADC linker that can be used in the design of antibody drug conjugates (ADCs), and it is a tripeptide which may be cleaved by legumain, a lysosomal protease.

Azido-PEG4-Ala-Ala-Asn is a unique peptide cleavable peptide linker with an azido group that will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases the aqueous solubility.