Lipids & Polymers

Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation motility and has a role in regulation cell shape. In addition S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca2+ homeostasis. Sphingosine 1-phosphate fluorescein is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with fluorescein.Excitation/Emission: 494/521 nmBulk quantities of this product are available. Please email echelon@echelon-inc.com for more information. Powered by Bioz See more details on BiozFeatured in Publications1) Peest U. S. C. Sensken et al. (2008). "S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake." J Cell Biochem 104(3): 756-72.2) Meissner A. J. Yang et al. (2012). "Tumor Necr

Azido-PEG3-acid is a crosslinker containing an azide(N3) group with a carboxylic acid (CO2H). The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Aminooxy-PEG1-azide is a short PEG linkerwith two functional groups, aminooxy (ONH2) and azide(N3). Aminooxy group can be used in bioconjugation by reaction with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

DBCO-mPEG, MW 2,000 is a cyclooctyne functional PEG polymer for bioorthogonal reaction with azide molecule. The Cu-free Click Chemistry or SPAAC is a highly efficient reaction while other naturally occurring functional group, such as amines, remains inert. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Fmoc-PEG4-hydroxy is a PEG linker containing an Fmoc-protected amine and a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Phosphatidylethanol (PEth) is formed primarily by transphosphatidylation of phosphatidylcholine (PC) by phosphlipase D. Most PEth (about 75%) is incorporated into erythrocyte membranes and is one of the longest-lived circulating EtOH metabolite yet identified. 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol-d5 (d5-POPEth) has a fully deuterated ethanol headgroup and can be used as a mass spectrometry standard.

Cardiolipin (CL) is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphatediacylglycerol. Due to its four acyl chains and small head group CL can organize into domains which can be proton sinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus.The free acid is being discontinued please use the ammonium salt as a replacement (cat# L-C161) Powered by Bioz See more details on Bioz

MW 70,000 Da

DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.