Angiogenesis is the growth process of new blood vessels from pre-existing one’s. It’s a normal physiological process, observed during embryonic development. But it’s also a pathological process, essentially in the growth of malignant tumors and metastasis development.
Angiogenesis is controlled by different activators and inhibitors made by healthy and tumoral cells.
Angiogenetic factors
A large offer of cytokines and growth factors are able to help you in your angiogenesis research.
- Fibroblast Growth Factor-basic: a member of the fibroblast growth factor family (hum FGF-basic, mur FGF-basic, rat FGF-basic)
- Vascular Endothelial Growth Factor: a potent growth & angiogenic cytokine ( hum VEGF 121, hum VEGF 165, mur VEGF 165)
- Epidermal Growth Factor: a growth factor that stmulates cell growth, proliferation and differention by binding to its receptor EGFR (hum EGF, mur EGF, rat EGF)
- Platelet-derived growth factor: one of the numerous growth factors, or proteins that regulate cell growth and division (hum PDGF-BB, mur PDGF-BB)
- Stem beads FGF2: a revolutionary growth factor supplement that offers a more efficient way to grow FGF2 dependent stem cell cultures
- Stem beads EGF: a growth factor that stimulates proliferation of many cell types including stem cells
Anti-Angiogenetic factors
The growth of angiogenesis is blocked by angiogenesis inhibitors. Endogenous inhibitors are found in the body naturally and are involved in the day-to-day process of regulating blood vessel formation. Here are some anti-Angiogenetic factors.
- Endostatin: an anti-angiogenetic factors that blocks the pro-angiogenic activities of VEGF and FGF-basic
- PF-4: a small cytokine inhibitis angiogenesis (hum PF-4, mur PF-4)
- Interferons (IFNs): theses cytokines are divised into three major types (hum IFN-alpha, hum IFN-ß, hum IFN-gamma, mur IFN-alpha, mur IFN-ß, mur IFN-gamma, rat IFN-Alpha, rat IFN-ß, rat IFN-gamma )
- Interleukins: a group of cytokines that were first seen to be expressed by white blood cells (hum IL-4, mur IL-4, rat IL-4, hum IL-12, mur IL-12)
- Mammary serine protease inhibitor: a non-inhibitory serpin that inhibit angiogenesis and to preferentially promote apoptosis of tumor cells
Any doubt about the best factors for your research?
Contact your local tebu-bio representatives to find the tools suited to your needs.
[contact-form to=’ali.el.baya@tebu-bio.com’ subject=’Cytokines and growth factors…’][contact-field label=’Nom’ type=’name’ required=’1’/][contact-field label=’Email’ type=’email’ required=’1’/][contact-field label=’Commentaire’ type=’textarea’ required=’1’/][/contact-form]
