The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines, growth factors and Interferons interact with the JAK/STAT signaling pathway which in turn regulates many biological processes, especially in hematopoietic development and immune responses.
The signaling is initiated upon the binding of cytokines (like Cardiotrophin-1, IFNs, LIF, TGF, EGF, bFGF…) to their cognate receptors causing receptor dimerization and trans-phosphorylation of the recruited JAKs. Once activated, JAKs phophorylate the STAT family members. These p-STATs in turn translocate to the nucleus and act as dimers to regulate the expression of target genes acting as transcription factors.
Dysregulation of JAK-STAT signaling leads to several immune disorders, such as hyperlgE syndrome, erythremia, and leukemia.
A selection of 100% guaranteed research antibodies related to the JAK-STAT pathway
- JAK1 antibody: a rabbit polyclonal antibody to JAK1 (Janus kinase 1)
- JAK2 antibody: a rabbit monoclonal antibody (clone EPR108(2) ) to JAK2
- STAT4 antibody: a rabbit polyclonal antibody to STAT4
- IFNGR1 antibody: a rabbit polyclonal antibody to IFNGR1
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