Chemicals

Farnesoic acid ((2E 6E)-3 7 11-trimethyldodeca-2 6 10-trienoic acid) is the substrate of farnesoic acid O-methyltransferase which produces the crustacean reproductive hormone methyl farnesoate (MF). MF is responsible for enhancing reproductive maturation maintaining juvenile morphology and influencing male sex determination. Farnesoic acid also inhibits filiment formation in C. albicans. Powered by Bioz See more details on BiozFeatured in Publications1) Li Y. G. C. Unnithan et al. (2003). "Stimulation of JH biosynthesis by the corpora allata of adult female Aedes aegypti in vitro: effect of farnesoic acid and Aedes allatotropin." J Exp Biol 206(Pt 11): 1825-32.2) Zhao N. J. Guan et al. (2007). "Molecular cloning and biochemical characterization of indole-3-acetic acid methyltransferase from poplar." Phytochemistry 68(11): 1537.3) Chung S.-C. T.-I. Kim et al. (2010). "Candida albicans PHO81 is required for the inhibition of hyphal development by farnesoic acid." FEBS letter

Methyl farnesoate (MF) is a crustacean reproductive hormone that is structurally similar to insect juvenile hormone. It is responsible for enhancing reproductive maturation maintaining juvenile morphology and influencing male sex determination. Exposure of female Daphnids to increasing levels of MF increases the percentage of males in a brood in a dose-dependant manner. MF is endogenously produced in the mandibular organ and environmental factors such as salinity and temperature can influence hemolyph levels. Powered by Bioz See more details on BiozFeatured in Publications1) Olmstead A. W. and G. A. LeBlanc (2007). "The environmental-endocrine basis of gynandromorphism (intersex) in a crustacean." Int J Biol Sci 3(2): 77-84.2) Eads B. D. J. Andrews et al. (2007). "Ecological genomics in Daphnia: stress responses and environmental sex determination." Heredity 100(2): 184.3) Nagaraju G. P. C. and D. W. Borst (2008). "Methyl farnesoate couples environmental changes to testicular d

Nanocs provides a variety of chemically functionalized and bioconjugated dextran products with molecular weight ranged from 3,000 Da to 2,000 KDa. These functional dextrans were purified by size chromatography to remove non-conjugated molecules and ensure adequate applications both in-vitro and in-vivo. Dextrans are naturally synthesized polysaccharides with good water solubility, low toxicity and varied molecular weights. Dextrans modified with dyes and other biomolecules have been successfully used as long-term tracers for live cells.

This novel and selective probe for hydrogen sulfide (H2S) 7-azido-4-methylcoumarin (AzMC) is useful for monitoring cystathionine B-synthase (CBS) catalyzed reactions which play a critical role in human sulfur metabolism. Deactivated CBS is characterized by high plasma levels of homocysteine and H2S resulting in clinical manifestations of numerous disease states. AzMC used as a fluorgenic probe and concurrent CBS activity can be used to select compounds for activation or inhibition of this enzyme and is suitable for high-throughput screening and the development of potential therapeutics. In addition AzMC has been used as a photoaffinitry probe for the substrate binding site of human phenol sulfotransferase (SULT1A-1 or P-PST-1).Featured in References1. M.K. Thorson T. Majtan J.P. Kraus A.M. Barrios "Identification of Cystathionine β-Synthase Inhibitors Using a Hydrogen Sulfide Selective Probe." Angewandte Chemie (Int. ed. Eng.) 2013 52 4641-4144. DOI: 10.1002/anie.20130084

C6NIB is a fluorescence turn-on sensor that is suited for trace vapor detection of hydrogen peroxide (H2O2). The sensor mechanism is based on H2O2-mediated oxidation of the boronate fluorophore C6NIB which is nonfluorescent in the ICT band but is strongly fluorescent upon conversion to the phenol (C6NIO). The fluorescence turn-on reaction is extremely sensitive towards H2O2 with no sensor response to other common reagents. The negligible fluorescence background of C6NIB combined with the high fluorescent emission of C6NIO makes it an ideal candidate for efficient sensing. Dispersing C6NIB with TBAH into a silica gel matrix produces a highly efficient sensor for vapor detection of H2O2 in terms of detection limit (2.9 ppb) and response time (1 sec. under 1 ppm H2O2).References:M. Xu J-M. Han et al.“A selective fluorescence turn-on sensor for trace vapor detection of hydrogen peroxide” Chem. Commun. 2013 49 11779-11781.

Hypoxia Inducible Factor (HIF) regulates responses to hypoxia and is comprised of two subunits alpha and beta. Upon cellular exposure to hypoxic conditions the HIF complex (alpha and beta subunits) is stabilized and binds to DNA transcriptionally activating genes linked to the cellular processes of angiogenesis and glucose metabolism1. Under normal conditions the HIF-alpha subunit is hydroxylated by the enzyme HIF-alpha prolyl hydroxylase (HIF-PH) leading to ubiquitylation of HIF-alpha and subsequent destruction2. DMOG (dimethyloxalylglycine) is a cell permeable competitive inhibitor of HIF-alpha prolyl hydroxylase (HIF-PH) leading to the stabilization of HIF and subsequent angiogenesis and glucose metabolism at concentrations between 0.1 and 1 mM3 4References1) Ivan M. K. Kondo et al. (2001). "HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing." Science 292(5516): 464-8.2) Jaakkola P. D. R. Mole et al. (2001). "Targeting of HI

NOG is an analogue of alpha ketoglutarate and has been found to be an inhibitor of reactions involving alpha ketoglutarate such as xanthine hydroxylase and alpha ketoglutarate dioxygenase.References1) Montero-Moran G. M. M. Li et al. (2007). "Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans." Biochemistry 46(18): 5293-304.2) Kalliri E. P. K. Grzyska et al. (2005). "Kinetic and spectroscopic investigation of CoII NiII and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase TauD." Biochem Biophys Res Commun 338(1): 191-7.

Monobromobimane reacts with thiols sulfide thiosulfate and sulfite to generate a fluorescent product with excitation/emission maxima at 394/490 nm.Publications Powered by Bioz See more details on Bioz1) Gainer H. and N. S. Kosower (1980). "Histochemical demonstration of thiols and disulfides by the fluorescent labeling agent monobromobimane: An application to the hypothalamo-neurohypophysial system." Histochemistry 68(3): 309-315.2) Hulbert P. B. and S. I. Yakubu (1983). "Monobromobimane: a substrate for the fluorimetric assay of glutathione transferase." Journal of Pharmacy and Pharmacology 35(6): 384.3) Alkhalfioui F.; Renard M.; Vensel W. H.; Wong J.; Tanaka C. K.; Hurkman W. J.; Buchanan B. B.; Montrichard F. (2007) Thioredoxin-linked proteins are reduced during germination of Medicago truncatula seeds. Plant Physiol. 144(3): 1559-79. 4) Catania J. M. A. M. Pershing et al. (2007). "Precision-cut tissue chips as an in vitro toxicology system." Toxicology in Vitro 2