Activators & Inhibitors

TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analog of thyrotropin-releasing hormone.

Tetrazine-Ph-acid is an alkyl chain-derived PROTAC linker employed in PROTAC synthesis[1].

VU0453379 is a highly selective and central nervous system penetrant positive allosteric modulator of glucagon-like peptide-1R (EC50: 1.3 μM).

4-Methyl-4-(methyldisulfanyl)pentanoic acid is an ADC linker employed in the synthesis of antibody-drug conjugates (ADCs) that can be cleaved.

AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker utilized for the synthesis of PROTAC IRAK4 degrader-1[1].

Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.

Cyclooctyne-O-PFP ester is a used as an ADC cytotoxin, which connects antibody and linker[1].

DBCO-CONH-S-S-NHS ester is a disulfide-linked ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Lenalidomide-C4-NH2 hydrochloride is a Cereblon ligand derived from Lenalidomide. It serves as a recruiting agent for the CRBN protein. The compound, known as PROTAC (Compound 24), can be formed by linking Lenalidomide-C4-NH2 hydrochloride to the ligand for the protein. It exhibits inhibitory effects with IC50s of 0.98 nM and 13.7 nM against the growth of RS4;11 and MOLM-13 acute leukemia cell lines, respectively[1].