Lipids & Polymers

Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].

m-PEG17-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Phosphatidylcholine (PC) Lipid Microparticles, pHrodoTM Red are beads with attached phosphatidylcholine and pHrodoTM Red. The PC headgroups are exposed and available for biological interactions. PC is primarily an extracellular phospholipid of cell membranes and is a key structural lipid. This product is intended as a negative control when using PS lipid microparticles in apoptosis or in phagocytosis studies. pHrodo is a trademark of ThermoFisher Scientific.