Lipids & Polymers

N-bis(Amine-PEG8)-N-(PEG8-t-butyl ester) is a 3-arm PEG linker consisting of a t-butyl ester with two amino groups. The amino (NH2) groups are reactive with activated NHS esters or carboxylic acid. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Reagent grade, for research purpose.

(Z)-non-2-enyl 6-bromohexanoate, also known as D-Desthiobiotin, is an analogue of Biotin and a protein cross-linking agent. (Z)-non-2-enyl 6-bromohexanoate binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin. It is used in the preparation of agarose matrices for affinity-based isolation of streptavidin-fluorophore conjugates. Reagent grade, for research purpose.

3,4-Dibromo-Mal-PEG4-amide-DBCO is a PEG linker containing a dibromomaleimide group and a terminal DBCO group. The dibromomaleimide group allows for two points of attachement because both of the bromine atoms can be substituted. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. PEG linkers are hydrophilic moieties, therefore the attachment of a PEG linker to a compound increases it's water solubility properties in aqueous media. Reagent grade, for research purpose.

14-(Azide-PEG5-ethylcarbamoyl)tridecanoic t-butyl ester is a PEG linker with an azide group and an alkane tail that has a terminal t-butyl ester group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

16-(Amine-PEG3-ethylcarbamoyl)pentadecanoic-t-butyl ester has an amine group on a PEG linker with a alkane tail that has a t-butyl ester group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. 16-(Amine-PEG3-ethylcarbamoyl)pentadecanoic-t-butyl ester is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

18-(Amine-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester is a PEG linker with an amine group and an alkane tail that has a terminal t-butyl ester group. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

18-(Bromoacetamido-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester has a bromide group on a PEG linker with a alkane tail that has a t-butyl ester group. The bromide (Br) can be used as a leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. 18-(Bromoacetamido-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.

18-(NHS ester-methylamine-PEG3-ethylcarbamoyl)heptadecanoic-t-butyl ester is a PEG linker with an NHS ester group and an alkane tail that has a terminal t-butyl ester group. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The polymer can form micelles spontaneously in water. It may also be used to prepare more complex lipids for nanoparticles for drug delivery. Reagent grade, for research purpose.

18-(Bromoacetamido-PEG3-ethylcarbamoyl)heptadecanoic acid has a bromide group on a PEG linker with a alkane tail that has a carboxylic acid group. The bromide (Br) can be used as a leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. 18-(Bromoacetamido-PEG3-ethylcarbamoyl)heptadecanoic acid is a self-assembling PEG reagent which may form micelles in water. This compound may also be used as a building block for lipids in nanotechnolgy and drug delivery. Reagent grade, for research purpose.