Lipids & Polymers

1,1'-[2-[( 6-bromohexanoate)methyl]-1,3-propanediyl] dipentadecan-7-yl adipate has a terminal bromide group and two 4,4-bis(octyloxy)butanoic acid tails. This compound can be useful for the building or modification of lipid nanoparticles. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose.

DBCO-PEG-NHS ester, 2,000 MW is a click chemistry poly PEG reagent containing NHS ester that is able to react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long and flexible connection that minimizes steric hindrance involved with ligation. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research purpose.

N-bis(Azido-PEG8)-N-(PEG8-t-butyl ester) is a 3-arm PEG reagent with a t-butyl ester group and two azide groups. The t-butyl ester groups can be deprotected under acidic conditions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Reagent grade, for research purpose.

Amine-PEG5-c18-t-butyl ester is comprised of an octadecanedioic acid with a PEG linker and a terminal amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with activated NHS esters to form a stable amide bond. Reagent grade, for research purpose.

1,2-Di-O-tetradecyl-rac-glycerol is a hydrophobic compound that has been found to occure naturally in the body. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. It has been shown to inhibit folic acid metabolism, and can be used as an immunoregulator in vitro. Reagent grade, for research purpose.

2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a linker containing a maleimide group with a terminal carboxylic acid. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid can be used in the synthesis of glycan probes. Reagent grade, for research purpose.

Benzyl-PEG-OH, 5,000 MW is a poly PEG linker with an acid labile, benzyl protecting group and a reactive primary alcohol. The primary alcohol can react and further derivatize the compound. The hydrophilic poly PEG linker increases the water solubility of the compound in aqueous media. Reagent grade, for research purpose.

DBCO-PEG6-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.

DSPE-PEG-endo-BCN, MW 2,000 is a click chemistry reagent with a BCN group attached to a poly PEG linker with hydrophobic lipid tails. The BCN group enable copper free click chemitry with azide-tagged molecules. Reagent grade, for research purpose.