Lipids & Polymers

Bis-PEG3-biotin is a biotinylation reagent with two terminal biotin groups. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein or macromolecule. Reagent grade, for research use only.

DSPE-PEG-amine TFA salt, MW 2,000 is a PEG polymer containing DSPE and amine end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group can react with activated NHS ester to form a stable amide bond. Reagent grade, for research use only.

Amine-PEG4-Amide-Tri(3-methoxypropanamide-PEG10-Propargyl) Methane HCl salt is a crosslinker consisting of an amino group with three propargyl groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. Reagent grade, for research use only.

t-Boc-N-amido-PEG4-Amide-Tri-(propargyl-PEG10-ethoxymethyl)-methane is a branched crosslinker molecule with three terminal propargyl groups and a t-Boc protected aminooxy group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected amine can be deprotected under acidic conditions. Reagent grade, for research use only.

D-acid-PEG4-Thalidomide-5-(PEG4-acid) is a PROTAC linker that can react with two Amine containing moieties in the presence of Activator EDC or HATU Reagent grade, for research use only.

t-Boc-N-amido-PEG12-azide consist of an azide group, Boc-protected amino and 12 PEG units. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research use only.

Propane-1,3-(PEG12-DBCO),2-alcohol is a PEG linker containing two DBCO moieties and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only.

DSPE-hydrazone-mPEG2K is a phospholipid polyPEG with a hydrazone group which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. Hydrazone linkages are useful for coupling drugs to targeted antibodies where the linkage is stable at neutral pH, but is rapidly destroyed in the acidic environment of lysosomes of the cell. Reagent grade, for research use only.

DBCO-PEG2-amine is a PEG linker which contains DBCO and amine moieties. The DBCO group is commonly used in copper-free Click Chemistry reactions. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases the water solubility of the compound. Reagent grade, for research purpose.