Lipids & Polymers

NHS-PEG4-biotinidase resistant biotin is a biotinylation reagent with a terminal NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal biotinylation can react with amine molecules in the presence of activator EDC or HATU. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Reagent grade, for research use only.

TFP-PEG4-biotinidase resistant biotin is a biotin and TFP ester end group. The biotin group is reactive with primary amino (-NH2) compound to form stable, irreversible amide bonds. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. Reagent grade, for research use only.

TFP-PEG12-biotinidase is a biotin and TFP ester end group. The biotin group is reactive with primary amino (-NH2) compound to form stable, irreversible amide bonds. The hydrophilic PEG spacer arm imparts water solubility that is transferred to the biotinylated molecule. The TFP ester can react with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. Reagent grade, for research use only.

Bis-PEG3-biotin is a biotinylation reagent with two terminal biotin groups. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein or macromolecule. Reagent grade, for research use only.

DSPE-PEG-amine TFA salt, MW 2,000 is a PEG polymer containing DSPE and amine end groups. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG increases the water solubility of the overall compound allowing for the delivery of the drug. The amine group can react with activated NHS ester to form a stable amide bond. Reagent grade, for research use only.

Amine-PEG4-Amide-Tri(3-methoxypropanamide-PEG10-Propargyl) Methane HCl salt is a crosslinker consisting of an amino group with three propargyl groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl groups can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. Reagent grade, for research use only.

t-Boc-N-amido-PEG4-Amide-Tri-(propargyl-PEG10-ethoxymethyl)-methane is a branched crosslinker molecule with three terminal propargyl groups and a t-Boc protected aminooxy group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected amine can be deprotected under acidic conditions. Reagent grade, for research use only.

D-acid-PEG4-Thalidomide-5-(PEG4-acid) is a PROTAC linker that can react with two Amine containing moieties in the presence of Activator EDC or HATU Reagent grade, for research use only.

t-Boc-N-amido-PEG12-azide consist of an azide group, Boc-protected amino and 12 PEG units. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research use only.