Nucleic Acids

DNA was prepared from cell line 451Lu BR. 451Lu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451Lu BR cells produce xenograft tumors when injected into immunocompromised mice.

Total RNA was prepared from cell line 451Lu BR. 451Lu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451Lu BR cells produce xenograft tumors when injected into immunocompromised mice.

Total RNA was prepared from cell line 451Lu BR. 451Lu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451Lu BR cells produce xenograft tumors when injected into immunocompromised mice.

Total RNA was prepared from cell line 451Lu BR. 451Lu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451Lu BR cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM1026. WM1026 is a metastatic human melanoma cell line that displays pigmented and dendritic morphology. This cell line was established from a lymph node metastases of a patient. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell is wild type for PTEN, N-RAS, c-KIT, and CDK4. WM1026 cells produce xenograft tumors when injected into immunocompromised mice.

DNA was prepared from cell line WM1026. WM1026 is a metastatic human melanoma cell line that displays pigmented and dendritic morphology. This cell line was established from a lymph node metastases of a patient. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell is wild type for PTEN, N-RAS, c-KIT, and CDK4. WM1026 cells produce xenograft tumors when injected into immunocompromised mice.

Total RNA was prepared from cell line WM1026. WM1026 is a metastatic human melanoma cell line that displays pigmented and dendritic morphology. This cell line was established from a lymph node metastases of a patient. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell is wild type for PTEN, N-RAS, c-KIT, and CDK4. WM1026 cells produce xenograft tumors when injected into immunocompromised mice.

Total RNA was prepared from cell line WM1026. WM1026 is a metastatic human melanoma cell line that displays pigmented and dendritic morphology. This cell line was established from a lymph node metastases of a patient. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell is wild type for PTEN, N-RAS, c-KIT, and CDK4. WM1026 cells produce xenograft tumors when injected into immunocompromised mice.