Lipids

C24:1 Ceramide is a lipid featuring two monounsaturated hydrophobic tails. Ceramides may be used in developing lipid nanoparticles or liposomes.

DOPE-Mal is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions with a terminal maliemide group. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Heptyl 8-bromooctanoate is an ester compound that has a terminal bromide group. Heptyl 8-bromooctanoate is formed by coupling 8-Bromooctanoic acid to Heptanol. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cholesteryl chloroformate is used in the preparation of hydrophobized chitosan oligosaccharide and can be used in the application as an efficient gene carrier. Cholesteryl chloroformate acts as an initiator in the polymerization of methyl methacrylate. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

98N12-5 is a novel multi-tail ionizable lipids that has been used for efficient in vivo siRNA–delivery to the liver.

BAMEAO16B is a lipid nanoparticle. BAMEAO16B integrated with disulfide bonds, can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA in response to the reductive intracellular environment for genome editing. BAMEAO16B can be used for the research of gene editing. This product is provided as a solution in methyl acetate.

7-(3-hydroxypropylamino)heptyl 2-hexyldecanoate has a terminal hydroxide group and can be useful for the building or modification of lipid nanoparticles. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Lipid 301 is an ionizable lipid analogue of ALC-0315 featuring a propanolamine head and two carbamate tails at the C6 position relative to the amine, one being an undecyl tail and the other being a branched C17. The ethanolamine head features an alcohol which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.

BP Lipid 302 is an ionizable lipid analogue of ALC-0315 featuring a butanolamine head and two carbamate tails at the C6 position relative to the amine, one being an undecyl tail and the other being a branched C17. The ethanolamine head features an alcohol which may be used for further derivatization. Ionizable lipids such as this may be applied in the development of lipid nanoparticles for drug discovery.