Results for Cells ( 28186 )
- From: €91.00
Using intestinal subcellular fractions as a test system is highly recommended due to the importance of intestinal enzymes in the first-pass metabolism of many orally ingested xenobiotics, including cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and esterase enzymes. Consequences of intestinal biotransformation can be very significant, including toxification by bioactivation and detoxification by aiding in excretion.We offer pooled intestinal subcellular fractions demonstrating high enzyme activity levels. Options include microsomes, S9, and cytosol, from matching large donor pools to minimize variability. Intestinal microsomes are supplied in 250 mM sucrose buffer. S9 and cytosolic fractions are supplied in a homogenization buffer with or without Phenylmethylsulfonyl flouride (PMSF). Please, contact your local Tebubio office for lot availability, specific criteria and to receive the lot-specific datasheet of your product.
- From: €382.00
Human liver microsomes contain a wide variety of drug metabolizing enzymes and are a recommended test system for assays including metabolite identification (MetID), metabolic stability, enzyme inhibition, reaction phenotyping, and other in vitro drug metabolism and pharmacokinetics (DMPK) studies. We offer pooled microsomes with representative averages of extensive and wide-ranging inter-individual differences in enzyme activity found in the general North America/USA population, as well as preparations from individual donors that have been genotyped for the presence of a specific single nucleotide polymorphism (SNP). Genotyped human liver microsomes can be used to investigate the influence of allelic variance on the safety and efficacy of new molecular entities. Please, contact your local Tebubio office for lot availability, specific criteria and to receive the lot-specific datasheet of your product.
- Ref: H1000.H15B+Sizes: AMY 4.0 million cells
- Ref: H1000.H15C+Sizes: AMY 6.0 million cells
- Ref: H1500.H15C+Sizes: AMY 6.0 million cells
- From: €394.00
Human liver microsomes contain a wide variety of drug metabolizing enzymes and are a recommended test system for assays including metabolite identification (MetID), metabolic stability, enzyme inhibition, reaction phenotyping, and other in vitro drug metabolism and pharmacokinetics (DMPK) studies. We offer pooled microsomes with representative averages of extensive and wide-ranging inter-individual differences in enzyme activity found in the general North America/USA population, as well as preparations from individual donors that have been genotyped for the presence of a specific single nucleotide polymorphism (SNP). Genotyped human liver microsomes can be used to investigate the influence of allelic variance on the safety and efficacy of new molecular entities. Please, contact your local Tebubio office for lot availability, specific criteria and to receive the lot-specific datasheet of your product.
- From: €151.00
S9 fraction is a mixture of unfractionated microsomes and cytosol containing a wide variety of drug-metabolizing enzymes and is commonly used as a preferred test system in several in vitro ADME (Absorption, Distribution, Metabolism, and Excretion) studies investigating phase I and phase II metabolism of a drug compound. S9 fractions are supplied at a concentration of 20 mg/mL, in 50 mM TRIS-HCI, (pH 7.4 at 4ºC) containing 150 mM KCI and 2 mM EDTA. Please, contact your local Tebubio office for lot availability, specific criteria and to receive the lot-specific datasheet of your product.