mRNA production
Whether you are looking for mini-scale mRNA production, optimisation of your mRNA sequence, or you want to gain long-term GMP production perspectives, you can rely on our expertise and our centralised solutions to optimise your project.
Tebubio's own lab has developed an optimised template for efficient in vitro mRNA synthesis and subsequent protein expression in mammalian cells
Mini scale
In order to find primary 'hit' mRNA over candidates, Tebubio's mini-scale production services enable synthesis from small quantity mRNAs to meet your screening needs.
- As low as µg-level mRNAs
- Short production time - from gene synthesis to mRNA in 4 weeks, from your pDNA to mRNA in 5 days.
- Cloning into our proprietary optimized vectors for high yield of mRNAs or you can use your own template
- Best translation efficiency and Reduced immunogenicity - your sequence will be optimised for best translation efficiency (U depletion, hairpin reduction, chemical modification...)
Our laboratory is in Europe, we can easily arrange pick-up of your samples from your lab for delivery to ours, at your convenience.
Scale Up
Continue testing the efficiency of your mRNA in vitro and in vivo:
Scale up at milligram level
Optimal protein yield and reduced cellular immune response: benefit from the best capping solutions from market leaders
Approach requirements of clinical assays: Access a wide variety of modification, treatment and purification options, move forward towards toxicology testing
GMP Production
Benefit from our long-term partnership with the mRNA market leader - we can facilitate your access to GMP projects and will accompany you throughout the GMP project.
As the leading manufacturer of mRNA, TriLink Biotechnologies has unparalleled experience, technical expertise, and state-of-the-art current Good Manufacturing Practice (cGMP) production facilities.
TriLink's Quality System
Meets ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients, Section 19, APIs for use in clinical trials
- Certified ISO 9001:2015
- Practices continual improvement
QCs and optional testing
In addition to synthesizing sequences, you can access different QCs to characterize the identity and the purity of your sequence. Besides, you can take advantage of a range of candidate screening services, including:
- Transfection studies
- Protein expressions studies (Microscopy or ELISA detection)
- Fluorescent mRNA detection (Beacon, fluorescent microscopy..)
- Innate vs. adaptive response studies
- Inflammatory response studies
- Cytotoxicity studies
What's the next mRNA production project we can do together?