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    Results for Antibiotics & Metabolites ( 133 )

      • Ref: 1059-1g
        Sizes: 1g
        From: £62.00

        against mycobacteria

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      • Ref: 1090-50g
        Sizes: 50g
        From: £129.00

        Aminoglycoside antibiotic

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      • Ref: T10330
        Sizes: 1 mg, 5 mg, 1 mL, 2 mg
        From: £44.00

        Antibiotic-5d is a synthetic antimicrobial compound. It exhibits moderate antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, fungi and yeast.

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      • Ref: T10946
        Sizes: 1 mg
        From: £38.00

        D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abiraterone is also an antagonist of androgen receptor.

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      • Ref: T12571
        Sizes: 5 mg, 10 mg
        From: £1,405.00

        PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.

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      • Ref: 10-1101
        Sizes: 100 mg, 20 mg
        From: £93.00

        Activity: Antibiotic . Function/Pharmacology: Mupirocin is a topical antibiotic/antibacterial.1 It inhibits isoleucyl-tRNA synthase. High level mupirocin resistance was found in 8.2% of Staphylococcus aureus and 15.6% of coagulase-negative staphylococci with high level resistance being more common in methicillin-sensitive S. aureus in comparison with methicillin-resistant S. aureus.2

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      • Ref: 10-1331
        Sizes: 1 mg, 5 mg
        From: £76.00

        Activity: Endogenous cholesterol metabolite . Function/Pharmacology: 24(S)-Hydroxycholesterol is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous agonist of the nuclear receptor LXR.2 It has been shown to induce cell death in neuroblastoma cells3, possibly via a necroptosis pathway4. 24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM).5 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications.6,7 It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.7

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      • Ref: 10-2108
        Sizes: 1 g, 5 g
        From: £99.00

        Activity: Antibiotic and FOXM1 inhibitor . Function/Pharmacology: Novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2)1-2. Displays antitumor activity. Induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression3. Chemical Name: Fermentation product from Streptomyces azureus

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      • Ref: 10-2227
        Sizes: 5 mg, 25 mg
        From: £82.00

        Activity: Macrolide antibiotic; Cytochrome P450 inhibitor . Function/Pharmacology: Macrolide antibiotic. Inhibits cytochrome P450 (IC50 = 0-5 µM), thus blocking CYP450-dependent drug oxidation.

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