FcRn: IgG Recycling HMEC-1 Cell Pool - 2 vials

The FcRn: IgG Recycling HMEC-1 Cell Pool is a HMEC-1 cell pool expressing Fc gamma receptor and transporter (FCGRT) (NM_004107.5) and beta-2-microglobulin (B2M) (NM_004048.4), separated by a T2A self-cleaving peptide, under the control of a CMV promoter, introduced into HMEC-1 cells via lentiviral transduction. This cell pool is designed to measure the uptake and recycling of human IgG antibodies (human FcRn does not bind mouse IgG).

This cell pool has been validated with Nivolumab, Rituximab, Trastuzumab, Basiliximab and Alirocumab.