Compound Libraries

A collection of 386 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies.

430 food additives;

A unique collection of 3274 compounds for high-throughput screening and high-content screening,

58 species of cyclic peptide molecules for high-throughput and high-content screening;

A unique collection of 2484 of orally active compounds for high-throughput screening and high-content screening.

Activity: Comprises 12 inhibitors of the various components of the Wnt pathway . Function/Pharmacology: The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription. Dysfunction in the Wnt/ß-catenin pathway is implicated in various cancers, liver disease, ALS, Alzheimer’s disease, bone disease, and cardiovascular disease.

Activity: Comprises 12 inhibitors of various ion channels involved in pain transmission . Function/Pharmacology: Neuropathic pain is caused by damage or dysfunction to peripheral or central nervous system nerve fibers and is frequently chronic in nature. Persistent increased excitability and spontaneous activity in neurons leads to chronic pain that is difficult to treat. As the perception of pain is frequently transmitted via the activation of various ion channels, pharmacological modulation of these channels offers great therapeutic potential.

Activity: Comprises 6 inhibitors of the polycomb-group proteins . Function/Pharmacology: The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response.