Click Chemistry

Alkynyl stearic acid can be used to identify and characterize the post-translational acylation of proteins with powerful Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Alkynyl palmitic acid can be used to identify and characterize the post-translational S-palmitoylation of proteins with Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Alkynyl myristic acid can be used to identify and characterize the post-translational myristylated proteins with Click Chemistry. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

I-BET-762 is cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain). I-BET-762 binds to BRD2 (1-473), BRD3 (1-434), and BRD4 (1-477) with high affinity (Kd = 61.3, 50.5, and 55.2 nM, respectively, by ITC) and effectively competes against tetra-acetylated H4 peptide for BRD2/3/4 binding (IC50 = 32.5, 42,4, and 36.1 nM, respectively), while exhibiting little affinity toward 5 other bromodomain-containing proteins (ATAD2, BAZ2B, CREBBP, PCAF, SP140). I-BET-762 is reported to downregulate the expression of the genes which are induced by LPS, thus causing the decreased expression of LPS-inducible cytokines and chemokines. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate. It contains a a protease-sensitive Val-Cit dipeptide, and a MMAE payload. The MMAE is a synthetic antineoplastic agent. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Cy5 DBCO is a linker of the cyanine5 dye. The addition of the DBCO molecule allows for the compound to undergo copper-free Click Chemistry reactions. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BP Fluor 488 azide is a popular labeling dye used in Click Chemistry reactions. It will react with the DBCO or other alkyne group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5- sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.

BP Fluor 647 Azide is a water-soluble, pH-insensitive from pH 4 to pH 10 bright, far-red fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. A significant advantage to using long wavelength dyes such as Cy5 or BP Fluor 647 dye over other fluorophores is the low autofluorescence of biological specimens in this region of the spectrum. BP Fluor 647 Azide can be reacted with terminal alkynes via a copper-catalyzed click reaction (CuAAC). It also reacts with strained cyclooctyne via a copper-free “click chemistry” reaction to form a stable triazole and does not require Cu-catalyst or elevated temperatures. The brightness and photostability of this dye are best suited to direct imaging of low-abundance targets. For the detection of low abundance targets or where significant increase in signal intensity is desired please consider using next generation azides probes containing an internal copper-chelating motif. Reagent grade, for research purpose. Please con