Results for Antibiotics & Metabolites ( 164 )
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Activity: Biologically active cholesterol metabolite . Function/Pharmacology: Metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of 25-hydroxycholesterol there must be alternate pathways of generation that have yet to be determined.1 Likewise, the biological role of 25-hydroxycholesterol remains somewhat unclear. 25-Hydroxycholesterol is frequently mentioned as an important regulator of cholesterol metabolism, but apparently normal cholesterol regulation in organisms with both high and low levels of the compound make this association unclear. More recent reports have linked 25-hydroxycholesterol and one of it’s metabolites to immunoregulatory roles2, but more information is needed before it’s clear if that is indeed a primary role for the compound. Chemical Name: 5-Cholesten-3β, 25-diol
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Activity: Anti-inflammatory / antibiotic . Function/Pharmacology: Sulfasalazine is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release the anti-inflammatory agent 5-aminosalicylic acid and the antibacterial agent sulfapyridine. It has also been found to be a specific inhibitor of NFkB (IC50 = 500 µM)2, inhibitor of IL-2 production of activated T lymphocytes3 and, TNFα and IL-1 synthesis in macrophages4. Sulfasalazine has more recently been shown to be inhibitor of the system Xc- cystine-glutamate antiporter.5,6 It was able to block cystine uptake causing depletion of glutathione resulting in compromised cellular redox defense and ultimately cessation of tumor growth. It has been studied for the treatment of breast, pancreatic, lymphoma, brain and other cancers. Chemical Name: 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic aci