Primary Antibodies

Purified Anti-PtdIns(4)P monoclonal antibody.Subclass: IgMSource: MouseApplications: ELISA Immunofluorescence Fluorescence Polarization Protein-Lipid Overlay (PIP Strip)Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4 5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex.Storage2-8 °C for up to 30 days -20 °C for greater than 30 days. Do not freeze thaw multiple times. Powered by Bioz See more details on BiozFeatured in Publications1) Weber S. S. C. Ragaz et al. (2006). "Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole." PLoS Pathog 2(5): e46.2) Blagoveshchenskaya A. F. Y. Cheong et al. (2008). "Integration of Golgi trafficking and growth facto

Purified Anti-PtdIns(4 5)P2 (2C11) monoclonal antibody.Subclass: IgMSource: MouseApplications: ELISA Immunofluorescence Protein-Lipid Overlay (PIP Strip)Clonality: Monoclonal 2C11Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.Storage2-8 °C for up to 30 days -20 °C for greater than 30 days. Do not freeze thaw multiple times Powered by Bioz See more details on BiozFeatured in Publications1) Terebiznik M. R. O. V. Vieira et al. (2002). "Elimination of host cell PtdIns(4 5)P(2) by bacterial SigD promotes membrane fissi

Purified Anti-Sphingosine 1-Phosphate (S1P) monoclonal antibody.Subclass: IgGk1Source: MouseApplications: ELISA Immunohistochemistry ImmunocytochemistryProduct Background: Sphingosine 1-Phosphate (S1P) is a key component of the sphingolipid signaling cascade. S1P initiates a proliferative pro-angiogenic and anti-apoptotic sequence of events contributing to cancer progression. Recently scientific literature has suggested that S1P is a potent tumorigenic growth factor that is likely released from tumor cells and that S1P may be a novel biomarker for early stage cancer detection. Sphingosine kinase has also been shown to be up-regulated in a variety of cancer types. S1P antibody (LT1002) was originally developed and patented at Lpath Therapeutics.StorageAntibody is stable for up to 1 year at -20 °C. Antibody is stable for 60 days at 4°C. Avoid repeated freeze/thaw cycles. Powered by Bioz See more details on BiozReferences1) Visentin B Reynolds G Sabbadini R. (2012) Immunohistochem

Purified Anti-PtdIns(3 4 5)P3 monoclonal antibody.Subclass: IgMSource: MouseApplications: ImmunofluorescenceProduct Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from dysregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.Storage: 2-8 °C for up to 30 days -20 °C for greater than 30 days. Do not freeze thaw multiple times. Powered by Bioz See more details on BiozProduct keywords: PIP3 PI(3 4 5)P3 PtdIns(3 4 5)P3 IgM anti-PIP3

Purified Anti-PtdIns(3 4 5)P3 monoclonal antibody.Subclass: IgG1Source: MouseApplications: ELISA Alphascreen Fluorescence Polarization Protein-Lipid Overlay (PIP Strip)Product Background: Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.Storage2-8 °C for up to 30 days -20 °C for greater than 30 days. Do not freeze thaw multiple times. Powered by Bioz See more details on BiozFeatured in Publications1) Sweeney G. R. R. Garg et al. (2004). "Intracellular delivery of phosphatidylin

Mouse anti-Derp2 (2H4-H10-D9) Biotinylated Antibody, 50 ug

Anti-BCMA-Anti-CD3-Avi-His-Tag is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in both ELISA binding assay to BCMA-biotin and functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of BCMA-CHO cells (BPS Bioscience #79500-H).

Anti-CD20-Anti-CD3 Fc format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD20-CHO cells (BPS Bioscience #79624-H).

Anti-CD19-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD19-CHO cells (BPS Bioscience #79561-H) that overexpress CD19.