Mouse anti-Annexin A1, clone MRQ-3 - 7 ml

Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 is a useful marker for identifying hairy cell leukemia cells. ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia, it is therefore a useful marker for identifying hairy cell leukemia cells. By contrast, B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villous lymphocytes and patients with variant hairy cell leukemia—as defined by current morphologic, phenotypic, and clinical criteria—are ANXA1-negative. Additionally, aberrant expression of Annexin A1 has been reported in certain types of breast and gastric carcinomas.