b-AP15 (NSC-687852) - 25 mg

Activity: DUB inhibitor . Function/Pharmacology: Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. b-AP15 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. Chemical Name: 3,5-bis[(4-Nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one