Toximaster® QC8 MPR Part11 Software - 1 ST

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI