Intelliscreen™ Wnt/β-catenin (canonical) Mini-Library - 1 library

Activity: Comprises 12 inhibitors of the various components of the Wnt pathway . Function/Pharmacology: The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription. Dysfunction in the Wnt/ß-catenin pathway is implicated in various cancers, liver disease, ALS, Alzheimer’s disease, bone disease, and cardiovascular disease. Chemical Name: null