AC1903 - 50 mg

Activity: TRPC5 blocker . Function/Pharmacology: A potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo. Chemical Name: 1-Benzyl-1H-benzoimidazol-2-yl)-furan-2-ylmethyl-amine