ABT-418 HCl - 25 mg

Activity: Nicotinic acetylcholine receptor agonist; cognition enhancer . Function/Pharmacology: Agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1 Displays anxiolytic activity in a rat model and was 6-fold more potent than diazepam.2 Reduces distractibility in a primate model3 and may have relevance in attention deficit hyperactivity disorder4. Improves cognition in Alzheimer’s disease patients.5 Chemical Name: 3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole hydrochloride