Page 2 - Scientific Library
HSCI's researchers switch skin cells into pain-sensing neurons
In a recent publication, Dr Clifford
Fluorescent ShK toxin for Kv1.3 ion channels
Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.
Don't miss any neurotrophin!
Neurotrophins are important biomarkers in Neurobiology, including stem cell development to neural lineages. BDNF and NGF are the ones being studied in most cases. However, it has been found that neurotrophins
Get your ELISA results before lunch!
ELISAs are widely used in biomarker-related studies, especially when a high number of samples is involved, and only a few biomarkers need to be quantified. That said, incubations can be somehow cumbersome,
Neuroregenerative effects of microtubule stabilizing Epothilone B
Epothilone B is a bioactive microtubule-stabilizing small molecule. This blood-brain barrier permeable coumpound belongs to the most popular potent cytoskeletal modeling molecules for in vitro
High resolution structure of the TRPA1 channel protein
One of the hottest news last month was the high resolution structure of the TRPA1 ion channel protein.
Pharmacological agents which alleviate Pain
Chronic pain of varying types including inflammatory pain, cancer pain and neuropathic pain is an increasing health problem for which there are inadequate therapeutic options.
Many new targets for
Focus on Actin - G-F Actin ratio measured in cells
In previous posts, I invited you to look at versatile methods to
- Visualize actin: Focus on Actin staining and visualization
- Measure
Venomous toxin ion channel modulators
Ion channels are proteins with pore-forming abilities. Their selective capabilities to let ions cross the cell membrane involves them in crucial cellular functions (controlling membrance potential, the
Ion channel over expressing cell lines for inhibitory screening
In a recent post on Venomous toxin ion channel modulators, we looked at toxin derived peptides to manipulate a wide variety of ion channels. These toxins can be used as tools to characterize