Anti-Apoptosis Inducing Factor (AIF) (RABBIT) Antibody - - 100 µg

Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation.  These changes are triggered by the activation of members of the caspase family, caspase activated DNase, and several novel proteins.  A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF).  Like cytochrome c and caspase-9, which are critical molecules in apoptosis, AIF localizes to mitochondria.  AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9.  AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis.  These effects occur in both isolated nuclei and in the nuclei of live cells treated by microinjection and with apoptosis stimuli.  AIF is highly conserved between human and mouse and is widely expressed