Page 12 - Scientific Library
Focus on the JAK-STAT pathway...
The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines,
IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake by Deak et al.
Deak AT et al. decipher the mechanisms by which mitochondria contribute to Ca2+ intracellular signaling. In their recent paper (1), they show that mitochondrial "Ca2+ buffering" close to the Endoplasmic
Distinctions between homogeneous bulk cancer cell tumors vs. Cancer Stem cell driven tumors by Pr. Clarke
Professor Alan Clarke, (Director of the European Cancer Stem Cell Research Institute) has recently given an overview of how Cancer Stem cell tumors differ from the conventional "homogenous bulk cancer
Obesity, Diabetes, Metabolic syndrome new research tools
Insulin and Glucagon are involved in glucose homeostasis in addition to other factors secreted by the adipose tissue (adipokines). Insulin and Glucagon are produced by the endocrine pancreas. While
Focus on the Hypoxia Pathway...
Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. Therefore, reliable markers for hypoxia represent both valuable diagnostic markers
How to measure Calcium in cell based assays?
In Pharma screening departments there is a strong need for Ca2+ measurement methods.
Why is this?
GPCRs (G Protein Coupled Receptors) are still major targets of pharmaceutical screenings.
Around 30-40%
Immunotherapy Screening - B7-1 / CD28 and B7-1 / CTLA4 Pathways in Drug Discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Immunotherapy Screening - A focus on PD-1/PD-L1/PD-L2 Pathway in drug discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
New hope for Ras inhibitors
Ras belongs to the family of small G-proteins and plays an important role in several signal transduction pathways involved in normal cell growth and differentiation. Over 30 years ago three isoforms of
Immunotherapy - BLTA:HVEM, CD47:SIRPα in drug discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Proteasome inhibitor approved by FDA for Myeloma retreatment
The U.S. Food and Drug Administration (FDA) has approved Velcade (Bortezomib) for the retreatment of adult patients with Multiple Myeloma who had previously responded to Velcade therapy and relapsed
Tumour microenvironment - inflammation and immunity
Following our series of posts on tumour microenvironment (TME) and the role of Cox-2/PGE2 signaling, I'd like today to focus on inflammation and immunity.
TME is a dynamic milieu influenced by numerous