Page 12 - Scientific Library

Following our series of posts on tumour microenvironment (TME) and the role of Cox-2/PGE2 signaling, I'd like today to focus on inflammation and immunity.

TME is a dynamic milieu

Cancer research is increasingly focusing on the tumour microenvironment (TME). Several studies have shown that tumours depend on external signals for maintenance and expansion. It is therefore needed to

Epigenetic modifications target DNA and Histone proteins.

One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types, by regulating

The Histone Demethylase FBXL10 (also known as NDY1, KDM2B, or JHDM1B) has been reported to demethylate histone H3K4me3.  By removing active Methyl Epigenetic marks on the chromatin, this "Epigenetic Eraser"

In the past, molecular motor proteins like kinesins have been investigated with macromolecular approaches. Recent research on kinesins has been focused on resolving how kinesin is regulated by intramolecular

Small GTP-binding proteins such as RhoA, Rac1, and Cdc42 are involved in regulating cell signalling pathways and impact a wide range of cellular processes, functions, and morphology. They bind and hydrolyze

Current cancer vaccine strategies strive to efficiently deliver

DNA and Histone proteins are targets for epigenetic modifications.

One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types,

Cytoskeletal live cell imaging is extremely powerful when investigating cellular processes such as cytokinesis, motility and organelle transport and organization. The current experimental

Ras and Rho family members are small G proteins involved in the regulation of actin-dependent cell processes such as motility, growth, and intracellular trafficking. Furthermore, dysfunctions of Ras and

A lot of efforts are made to identify potent and selective inhibitors for the demethylation reactions catalyzed by members of the JMJD2 and JARID1 protein families (1, 2). Both

DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation