Page 11 - Scientific Library
Ferroptosis - and the way to inhibit it
A lot of compounds are known and available to modulate (inhibit or activate) the most prominent mode of programmed cell death - Apoptosis. In a recent post, I summarized methods to detect early Apoptosis
Differentiate between Apoptosis, Necroptosis, Autophagy & Ferroptosis
Cell death can be caused by external factors such as infection or trauma - a process which is call necrosis. On the other hand, cell death can be mediated by intracellular programs - in this cases we talk
Live cell imaging in action: Killer T-cells hunt their target
In a recent video posted on "Cambridge University's YouTube channel", Professor Gillian Griffiths and co-workers prove how the Life Science Community can benefit from modern and innovative cellÂ
Modulating or inhibiting Caspase activities
In a previous post, I discussed Caspases as pharmaceutical targets - how to screen for inhibitors?
Today I would like to concentrate on Caspase inhibitors/modulators, which allow for in-depth characterisation
3D monitoring of cell movement through Collagen I
The transition from non-invasive phenotype to invasive phenotype of tumor cells marks the switch from a benign tumor to a more malignant form of cancer. Understanding the mechanisms underlying this hallmark
D-dimer and Cardiovascular Disease
Fibrinogen is the main protein of the blood coagulation system. It consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. The process of blood coagulation results
Differentiate between K48- and K63-specific Ubiquitination
Ubiquitination is a common post translational protein modification that occurs through an isopeptide linkage between the C-terminus of ubiquitin and the ε-amino group of a lysine residue on the target
Flow cytometry intracellular staining
Intracellular Flow Cytometry enables the identification and analysis of signaling and functional markers within cells from samples containing heterogeneous cell populations. Many cell types can
Mechanism of action for angiogenesis inhibitor Borrelidin discovered
Originally identified as an active molecule against the Borrelia species, Borrelidin has since been described as a selective inhibitor of threonyl tRNA synthetase (ThrRS). More recent research has
IL-1 family quantified simultaneously...at last!
The IL-1 family has long been known as a key player in the effector role of macrophages in innate defence against tumours and infections. It plays an important role in the field of natural / innate immunity
