Page 6 - Scientific Library
8 new JARID1 - JMJD2 HMT assays
A lot of efforts are made to identify potent and selective inhibitors for the demethylation reactions catalyzed by members of the JMJD2 and JARID1 protein families (1, 2). Both epigenetic eraser enzyme
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
MDR1 activity enhancement reduces senescence markers
During the last International Federation of Societies of Cosmetic Chemists (IFSCC) congress (Paris, Oct. 2014), Hajem N. et al (ALES Groupe) have shown that by enhancing MDR activity of fibroblasts
Cell counting made easy!
After you've read this post, I hope that you'll agree that what the title of the post announces is the right assumption. How? Read on!
I invite you to take a look at Cyto-X, which is a ready-for-use
Easy and sensitive methods to measure antioxidative potential
Free radicals and reactive oxygen species (ROS) are highly reactive molecules that are generated by normal cellular processes, environmental stress, and UV irradiation. ROS react with cellular components,
Antibiotics and microbial metabolites - revisited
What are metabolites?
Microorganisms live in a world of chemical signals. They use small molecular weight compounds, known as metabolites, to regulate their own growth and development, to encourage other
How to measure Glycosaminoglycans and Proteoglycans?
Glycosaminoglycans (or mucopolysaccharides) are long un-branched polysaccherides which consist of disaccharide repeats. The repeats usually (with the exception of Keratan sulfate) consist of on amino sugar
New in vitro cellular model for human Lipodystrophy
Lipodystrophies are disorders characterized by complete or selective loss of adipose tissue from various regions of the body. They might lead to severe metabolic disorders. The development of reliable
Using CRISPR to knockout an essential gene
Genome editing technology enabled by CRISPR and TALEN has become mainstream. Most cell biology labs are engaged in projects to create custom cell lines with knock-outs and knock-ins, and companies such
A simple way to measure Elastin
Recently I reported about methods to measure:
- Collagen - Sircol for soluble and insoluble collagen assays
- Glycosaminoglycans - How to measure Glycosaminoglycans and Proteoglycans?
Today, I invite you to